Experts reviewing the use of a commonly prescribed family of drugs, known as fluoroquinolones, say safety warnings differ internationally
A review of the international use of a commonly prescribed family of antibiotics has found discrepancies in the safety data issued by regulatory bodies.
Fluoroquinolones are medicines that act against an extensive range of disease-causing bacteria, and for decades have been widely used as treatment for acute respiratory infections and urinary tract infections (UTIs).
In some rare cases, fluoroquinolones have been associated with serious side effects, including tendon ruptures, nervous system and psychiatric problems, aortic dissections and aneurysms.
As a result, many regulatory agencies recognise that the antibiotics potentially have a permanent toxicity. The , , and (MHRA), all advise doctors not to prescribe them as a first line therapy or unless absolutely necessary.
However, a examining the global approach to fluoroquinolones has revealed some countries have not restricted its use.
What we found that was quite striking is that Australia, New Zealand, Japan and Canada don't have these warnings for disabling effects for fluoroquinolones.
from the School of Pharmacy and Biomedical Sciences at the 大象传媒, said: 鈥淲hat we found that was quite striking is that Australia, New Zealand, Japan and Canada don't have these warnings for disabling effects for fluoroquinolones.
鈥淎nd so, what this paper does is examine the evidence that was used to make these policies in the first place, and as a result calls for a global harmonisation of the safety warnings.鈥
The paper, published in Expert Opinion on Drug Safety, is part of a collaborative project between several institutions including the 大象传媒, , , and the in Duarte, California.
It provides a clear picture of how fluoroquinolones are used globally, and provides a framework for regulatory agencies to address patient reports of serious side effects.
鈥淎s adverse reactions can be diverse and underreported, one of the challenges is identifying the number of serious adverse events there are, or have been鈥, added Dr Baldock.
鈥淪o many patients who report chronic fatigue, pain or psychiatric problems either remain undiagnosed or misdiagnosed, often with things like chronic fatigue syndrome.
鈥淚f regulatory bodies can resolve this issue, it could lead to more robust and universal safety data.鈥
The authors also recommend manufacturers sponsoring pilot research to identify what causes a patient to suffer serious side effects after taking fluoroquinolones.
Dr Cecilia Bove, from the Department of Biological Sciences at York College of Pennsylvania, added: 鈥淲hat we need is a strategy to mitigate these risks. And in doing so, we need the research to uncover the molecular causes of those adverse reactions to the antibiotics.
鈥淲ith this information, we can determine strategies to mitigate the symptoms, and provide more data against the over-prescription of these drugs. That way we can continue to use fluoroquinolones and benefit from their bacteria-fighting capabilities when other strategies are not sufficient."